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Beilstein J. Org. Chem. 2020, 16, 1875–1880, doi:10.3762/bjoc.16.155
Graphical Abstract
Scheme 1: Synthesis of chiral phosphoric acid 3.
Scheme 2: Synthesis of methylated chiral phosphoric acid 7.
Scheme 3: Control experiment with catalyst 7.
Figure 1: A plausible chiral transition-state structure in the Biginelli-like reaction catalyzed by phosphori...